1c:I[204933,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/959ed6555b8dc5ff.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T46f,Abstract The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions. The anatomy of the pathways is outlined in drawings of frontal sections of the brain and the origin and termination of several pathways is determined by studying the anterograde and retrograde degeneration occurring after well localised lesions. It is possible to separate the ascending NA pathways into a dorsal and a ventral bundle of axons. The dorsal bundle innervates the cortex and the hippocampus and the ventral bundle supplies NA nerve terminals to the medulla, the pons, the mesencephalon and the diencephalon. The dorsal bundle is found to originate in the locus coeruleus. Lesions of this nucleus abolish the nerve terminals in all cortical areas and in several other areas of the brain indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. The 5‐HT pathways have a distribution similar to the ventral NA pathyway. The course of the nigro‐striatal and the meso‐limbic DA pathways is presented in detail.1e:T409,The work of Cannon,¹Bard,²Penfield,³Ranson⁴and others has greatly advanced knowledge of the functions of the hypothalamus. In the light of these researches the connections of the hypothalamus to the medial wall of the cerebral cortex gain a new significance. The following discussion presents some anatomic, clinical and experimental data dealing with the hypothalamus, the gyrus cinguli, the hippocampus and their interconnections. Taken as a whole, this ensemble of structures is proposed as representing theoretically the anatomic basis of the emotions. It is generally recognized that in the brain of lower vertebrates the medial wall of the cerebral hemisphere is connected anatomically and integrated physiologically with the hypothalamus and that the lateral wall is similarly related to the dorsal thalamus (Herrick⁵). These fundamental relations are not only retained but greatly elaborated in the mammalian brain by the further development of the hippocampal formation1f:T589,

	Year	Citations